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SP1 Antibody

CAT: 0223-55-854Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-854Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation) . Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
NCBI Gene ID
6667
Swiss Prot
P08047
Accession Number
P08047
Host
Rabbit
Reactivity
Human
Immunogen
This SP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 677-707 amino acids from the C-terminal region of human SP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
81 kDa
Fragment
Rabbit Ig
Symbol
SP1
NCBI Official Name
Transcription factor Sp1
NCBI Organism
Homo sapiens
Background Reference 01
Pan, Q., et al. Biochem. Biophys. Res. Commun. 401 (2) :306-312 (2010)
Background Reference 02
Mucha, M., et al. J. Neurosci. 30 (40) :13235-13245 (2010)
Background Reference 03
Imanishi, M., et al. Biochem. Biophys. Res. Commun. 400 (4) :625-630 (2010)
Background Reference 04
Jutooru, I., et al. J. Biol. Chem. 285 (33) :25332-25344 (2010)
Other Product Names
Transcription factor Sp1, SP1, TSFP1
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
13638437
Physical Properties
Liquid

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