COCH Antibody

• Background:

  The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq].

• NCBI Gene ID:

  1690

• Swiss Prot:

  O43405

• Accession Number:

  O43405

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This COCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-520 amino acids from the C-terminal region of human COCH.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  59 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  COCH

• NCBI Official Name:

  Cochlin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ikezono, T., et al. Acta Otolaryngol. 130 (8) :881-887 (2010)

• Background Reference 02:

  Yao, J., et al. J. Biol. Chem. 285 (20) :14909-14919 (2010)

• Background Reference 03:

  Baek, J.I., et al. Clin. Genet. 77 (4) :399-403 (2010)

• Background Reference 04:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Other Product Names:

  Cochlin, COCH-5B2, COCH, COCH5B2

• Tested Applications:

  WB

• Physical Properties:

  Liquid