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MNDA Antibody

CAT: 0223-55-731Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-731Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.
NCBI Gene ID
4332
Swiss Prot
P41218
Accession Number
P41218
Host
Rabbit
Reactivity
Human
Immunogen
This MNDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of human MNDA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
46 kDa
Fragment
Rabbit Ig
Symbol
MNDA
NCBI Official Name
Myeloid cell nuclear differentiation antigen
NCBI Organism
Homo sapiens
Background Reference 01
Kimkong, I., et al. J. Rheumatol. 37 (7) :1544-1547 (2010)
Background Reference 02
Kanellis, G., et al. Leukemia 23 (10) :1847-1857 (2009)
Background Reference 03
Joshi, A.D., et al. Clin. Cancer Res. 13 (18 PT 1), 5295-5304 (2007) :
Background Reference 04
Briggs, R.C., et al. Cancer Res. 66 (9) :4645-4651 (2006)
Other Product Names
Myeloid cell nuclear differentiation antigen, MNDA
Tested Applications
WB, IHC-P, Flow
Protein ID
730038
Physical Properties
Liquid

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