ENG Antibody

• Background:

  This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  2022

• Swiss Prot:

  P17813

• Accession Number:

  P17813

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ENG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the Central region of human ENG.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  71 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ENG

• NCBI Official Name:

  Endoglin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lopez-Novoa, J.M., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (4), H959-H974 (2010) :

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Zabaneh, D., et al. PLoS ONE (8), E11961 (2010) :

• Background Reference 04:

  Maynard, S.E., et al. Hypertens Pregnancy 29 (3) :330-341 (2010)

• Other Product Names:

  Endoglin, CD105, ENG, END

• Tested Applications:

  WB, Flow

• Protein ID:

  3041681

• Physical Properties:

  Liquid