EAPII Antibody

• Background:

  This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.

• NCBI Gene ID:

  51567

• Swiss Prot:

  O95551

• Accession Number:

  O95551

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EAPII antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246-272 amino acids from the C-terminal region of human EAPII.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  41 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TDP2

• NCBI Official Name:

  Tyrosyl-DNA phosphodiesterase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 02:

  Wang, B.Y., et al. Mol. Biol. Rep. 37 (6) :2809-2816 (2010)

• Background Reference 03:

  Iijima, M., et al. Neurology 73 (17) :1348-1352 (2009)

• Background Reference 04:

  Cortes Ledesma, F., et al. Nature 461 (7264) :674-678 (2009)

• Other Product Names:

  Tyrosyl-DNA phosphodiesterase 2, Tyr-DNA phosphodiesterase 2, hTDP2, 314-, 5'-tyrosyl-DNA phosphodiesterase, 5'-Tyr-DNA phosphodiesterase, ETS1-associated protein 2, ETS1-associated protein II, EAPII, TRAF and TNF receptor-associated protein, Tyrosyl-RNA phosphodiesterase, VPg unlinkase, TDP2, EAP2, TTRAP

• Tested Applications:

  WB, IHC-P, IF, Flow

• Physical Properties:

  Liquid