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CTNB1 Antibody

CAT: 0223-55-721Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-721Size:400 µL
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Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
NCBI Gene ID
1499
Swiss Prot
P35222
Accession Number
P35222
Host
Rabbit
Reactivity
Human
Immunogen
This CTNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 646-673 amino acids from the C-terminal region of human CTNB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Drosophila, Bovine, Mouse, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
85 kDa
Fragment
Rabbit Ig
Symbol
CTNNB1
NCBI Official Name
Catenin beta-1
NCBI Organism
Homo sapiens
Background Reference 01
Huang, W., et al. Mol. Cell. Biol. 30 (19) :4575-4594 (2010)
Background Reference 02
Chairoungdua, A., et al. J. Cell Biol. 190 (6) :1079-1091 (2010)
Background Reference 03
Mirza, M.K., et al. J. Exp. Med. 207 (8) :1675-1685 (2010)
Background Reference 04
Guo, Q., et al. Acta Biochim. Biophys. Sin. (Shanghai) 42 (7) :450-456 (2010)
Other Product Names
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Tested Applications
WB, IHC-P, IF
Protein ID
461854
Physical Properties
Liquid

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