CTNB1 Antibody

• Background:

  The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

• NCBI Gene ID:

  1499

• Swiss Prot:

  P35222

• Accession Number:

  P35222

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CTNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 646-673 amino acids from the C-terminal region of human CTNB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Drosophila, Bovine, Mouse, Rat, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  85 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CTNNB1

• NCBI Official Name:

  Catenin beta-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Huang, W., et al. Mol. Cell. Biol. 30 (19) :4575-4594 (2010)

• Background Reference 02:

  Chairoungdua, A., et al. J. Cell Biol. 190 (6) :1079-1091 (2010)

• Background Reference 03:

  Mirza, M.K., et al. J. Exp. Med. 207 (8) :1675-1685 (2010)

• Background Reference 04:

  Guo, Q., et al. Acta Biochim. Biophys. Sin. (Shanghai) 42 (7) :450-456 (2010)

• Other Product Names:

  Catenin beta-1, Beta-catenin, CTNNB1, CTNNB

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  461854

• Physical Properties:

  Liquid