Beta Catenin Antibody [CTNNB1/1509]

• Background:

  Beta-Catenin associates with the cytoplasmic portion of E-Cadherin, which is necessary for the function of E-Cadherin as an adhesion molecule. In normal tissues, beta-Catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-Catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immunostaining of beta-Catenin and E-Cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

• NCBI Gene ID:

  1499

• Swiss Prot:

  P35222

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A partial human recombinant protein was used as the immunogen for the b-Catenin antibody.

• Clonality:

  Monoclonal

• Clone:

  CTNNB1/1509

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Symbol:

  CTNNB1

• NCBI Official Name:

  Catenin (cadherin-associated protein), beta 1, 88kDa

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Catenin beta-1, Beta-catenin, CTNNB1, CTNNB

• Tested Applications:

  IHC-P, Flow, IF, WB

• Physical Properties:

  Liquid