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GAD1 Antibody

CAT: 0223-55-719Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-719Size:400 µL
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Background
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
NCBI Gene ID
2571
Swiss Prot
Q99259
Accession Number
Q99259
Host
Rabbit
Reactivity
Human
Immunogen
This GAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 514-543 amino acids from the C-terminal region of human GAD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
67 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GAD1
NCBI Official Name
Glutamate decarboxylase 1
NCBI Organism
Homo sapiens
Background Reference 01
Lanoue, A.C., et al. Exp. Neurol. 226 (1) :207-217 (2010)
Background Reference 02
Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :
Background Reference 03
Terranova, C., et al. Alcohol 44 (5) :407-413 (2010)
Background Reference 04
Ruano, G., et al. Pharmacogenomics 11 (7) :959-971 (2010)
Other Product Names
Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD, GAD67
Tested Applications
WB
Protein ID
1352213
Physical Properties
Liquid

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