CCNH Antibody

CAT: 0223-55-706Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-706Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK) . This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
NCBI Gene ID
902
Swiss Prot
P51946
Accession Number
P51946
Host
Rabbit
Reactivity
Mouse
Immunogen
This CCNH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human CCNH.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Symbol
CCNH
NCBI Official Name
Cyclin-H
NCBI Organism
Homo sapiens
Background Reference 01
Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)
Background Reference 02
Hosgood, H.D. III, et al. Respir Med 103 (12) :1866-1870 (2009)
Background Reference 03
Young, R.P., et al. Postgrad Med85 (1008) :515-524 (2009)
Background Reference 04
Kweekel, D.M., et al. Br. J. Cancer 101 (2) :357-362 (2009)
Other Product Names
Cyclin-H, MO15-associated protein, p34, p37, CCNH
Tested Applications
WB, Flow
Protein ID
1706232
Physical Properties
Liquid

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