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INHBA Antibody

CAT: 0223-55-651Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-651Size:400 µL
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Background
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
NCBI Gene ID
3624
Swiss Prot
P08476
Accession Number
P08476
Host
Rabbit
Reactivity
Human
Immunogen
This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the N-terminal region of human INHBA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Symbol
INHBA
NCBI Official Name
Inhibin beta A chain
NCBI Organism
Homo sapiens
Background Reference 01
Canzian, F., et al. Hum. Mol. Genet. 19 (19) :3873-3884 (2010)
Background Reference 02
Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :
Background Reference 03
Lascorz, J., et al. Carcinogenesis 31 (9) :1612-1619 (2010)
Background Reference 04
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Other Product Names
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
124279
Physical Properties
Liquid

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