GluR2 Antibody

• Background:

  The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR) . The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994) . The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD (Chung et al., 2003)

• NCBI Gene ID:

  29627

• Swiss Prot:

  P19491

• Accession Number:

  P19491

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Chicken, Zebrafish

• Immunogen:

  Peptide corresponding to amino acid residues from rat GluR2, conjugated to keyhole limpet hemocyanin (KLH) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  GluR2 antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight:

  100

• Applications Notes:

  The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will also react with chicken, human, mouse, non-human primates and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

• Symbol:

  Gria2

• NCBI Official Name:

  Glutamate receptor, ionotropic, AMPA 2

• NCBI Organism:

  Rattus norvegicus

• Background Reference 01:

  Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.

• Background Reference 02:

  Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.

• Background Reference 03:

  Keinänen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH (1990) A family of AMPA-selective glutamate receptors. Science 249:556-560.

• Tested Applications:

  WB

• Protein ID:

  3287964

• Physical Properties:

  Liquid