GluR2 Antibody

CAT: 0223-50-218Size: 0.1 mLDry Ice: NoHazardous: No
CAT#:0223-50-218Size:0.1 mL
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Background
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR) . The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994) . The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD (Chung et al., 2003)
NCBI Gene ID
29627
Swiss Prot
P19491
Accession Number
P19491
Host
Rabbit
Reactivity
Human, Mouse, Rat, Chicken, Zebrafish
Immunogen
Peptide corresponding to amino acid residues from rat GluR2, conjugated to keyhole limpet hemocyanin (KLH) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GluR2 antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Calculated Molecular Weight
100
Applications Notes
The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will also react with chicken, human, mouse, non-human primates and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Symbol
Gria2
NCBI Official Name
Glutamate receptor, ionotropic, AMPA 2
NCBI Organism
Rattus norvegicus
Background Reference 01
Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.
Background Reference 02
Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
Background Reference 03
Keinänen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH (1990) A family of AMPA-selective glutamate receptors. Science 249:556-560.
Tested Applications
WB
Protein ID
3287964
Physical Properties
Liquid

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