GRASP Antibody

• Background :

  PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000) . Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000) .

• NCBI Gene ID :

  116493

• Swiss Prot :

  Q9JHZ4

• Accession Number :

  Q9JHZ4

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat, Dog, Bovine

• Immunogen :

  Peptide corresponding to amino acid residues from the C-terminal region of rat GRASP, conjugated to keyhole limpet hemocyanin (KLH) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity Purified

• Concentration :

  Batch dependent

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  GRASP antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight :

  95

• Applications Notes :

  The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, human and mouse based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

• Symbol :

  Gripap1

• NCBI Official Name :

  GRIP1 associated protein 1

• NCBI Organism :

  Rattus norvegicus

• Background Reference 01 :

  Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1:133-141.

• Background Reference 02 :

  Ye B, Liao DZ, Zhang XQ, Zhang PS, Dong HL, Huganir RL (2000) GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26:603-617.

• Tested Applications :

  WB

• Protein ID :

  76363169

• Physical Properties :

  Liquid