PIDD Antibody

• Background :

  PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

• NCBI Gene ID :

  55367

• Swiss Prot :

  Q9HB75

• Accession Number :

  116242715

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant human PIDD (Death Domain: aa 776-910) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis, Cancer, Innate Immunity

• Concentration :

  1 mg/ml

• Buffer :

  Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Specificity :

  Recognizes human and the native form of mouse PIDD. Detects bands of ~90kDa (full length protein) and ~50kDa (cleaved protein) by Western blot.

• Applications Notes :

  Immunohistochemistry: (paraffin sections) . Immunoprecipitation: (1:100) . Western Blot: (1:500) .

• Symbol :

  PIDD1

• NCBI Official Name :

  P53-induced death domain protein 1

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  P53-induced Protein with a Death Domain; Leucine-rich Repeat and Death Domain-containing Protein; Lrdd

• Tested Applications :

  IHC, IP, WB

• Protein ID :

  Q9HB75

• Physical Properties :

  Liquid