PIDD Antibody

• Background:

  PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

• NCBI Gene ID:

  55367

• Swiss Prot:

  Q9HB75

• Accession Number:

  116242715

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant human PIDD (Death Domain: aa 776-910) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Innate Immunity

• Concentration:

  1 mg/ml

• Buffer:

  Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Specificity:

  Recognizes human and the native form of mouse PIDD. Detects bands of ~90kDa (full length protein) and ~50kDa (cleaved protein) by Western blot.

• Applications Notes:

  Immunohistochemistry: (paraffin sections) . Immunoprecipitation: (1:100) . Western Blot: (1:500) .

• Symbol:

  PIDD1

• NCBI Official Name:

  P53-induced death domain protein 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  P53-induced Protein with a Death Domain; Leucine-rich Repeat and Death Domain-containing Protein; Lrdd

• Tested Applications:

  IHC, IP, WB

• Protein ID:

  Q9HB75

• Physical Properties:

  Liquid