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IDO Antibody

CAT: 0223-36-228Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-36-228Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
NCBI Gene ID
3620
Swiss Prot
P14902
Accession Number
4504577
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human IDO.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Innate Immunity, Obesity
Concentration
1 mg/ml
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Specificity
Recognizes human IDO. Detects a band of ~45kDa by Western blot.
Applications Notes
ELISA: (direct and indirect: 1:2,000-1:10,000) . Flow Cytometry: (1:200-1:500) . Immunocytochemistry: (1:500) . Western Blot: (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature) . Optimal conditions must be determined individually for each application.
Symbol
IDO1
NCBI Official Name
Indoleamine 2,3-dioxygenase 1
NCBI Organism
Homo sapiens
Other Product Names
Indoleamine 2,3-dioxygenase; INDO
Tested Applications
ELISA, Flow, ICC, WB
Protein ID
NP_002155.1
Physical Properties
Liquid

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