KARS Antibody

• Background:

  Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  3735

• Swiss Prot:

  Q15046

• Accession Number:

  Q15046

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human KARS.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  68 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  KARS

• NCBI Official Name:

  Lysine--tRNA ligase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  McLaughlin, H.M., et al. Am. J. Hum. Genet. 87 (4) :560-566 (2010)

• Background Reference 02:

  Kepp, O., et al. Cell Cycle 9 (15) :3072-3077 (2010)

• Background Reference 03:

  Segat, L., et al. Vaccine 28 (10) :2201-2206 (2010)

• Background Reference 04:

  Dastani, Z., et al. Eur. J. Hum. Genet. 18 (3) :342-347 (2010)

• Other Product Names:

  Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS, KARS, KIAA0070

• Tested Applications:

  WB, Flow

• Protein ID:

  20178333

• Physical Properties:

  Liquid