KARS Antibody

• Background :

  Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID :

  3735

• Swiss Prot :

  Q15046

• Accession Number :

  Q15046

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This KARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human KARS.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Neuroscience, Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  68 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  KARS

• NCBI Official Name :

  Lysine--tRNA ligase

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  McLaughlin, H.M., et al. Am. J. Hum. Genet. 87 (4) :560-566 (2010)

• Background Reference 02 :

  Kepp, O., et al. Cell Cycle 9 (15) :3072-3077 (2010)

• Background Reference 03 :

  Segat, L., et al. Vaccine 28 (10) :2201-2206 (2010)

• Background Reference 04 :

  Dastani, Z., et al. Eur. J. Hum. Genet. 18 (3) :342-347 (2010)

• Other Product Names :

  Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS, KARS, KIAA0070

• Tested Applications :

  WB, Flow

• Protein ID :

  20178333

• Physical Properties :

  Liquid