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AIRE Antibody

CAT: 0223-55-609Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-609Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD) . Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) .
NCBI Gene ID
326
Swiss Prot
O43918
Accession Number
O43918
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This AIRE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human AIRE.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Symbol
AIRE
NCBI Official Name
Autoimmune regulator
NCBI Organism
Homo sapiens
Background Reference 01
Cervato, S., et al. Clin. Endocrinol. (Oxf) 73 (5) :630-636 (2010)
Background Reference 02
Ruano, G., et al. Pharmacogenomics 11 (7) :959-971 (2010)
Background Reference 03
Conteduca, G., et al. Clin. Immunol. 136 (1) :96-104 (2010)
Background Reference 04
Colome, N., et al. J. Proteome Res. 9 (5) :2600-2609 (2010)
Other Product Names
Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, APECED protein, AIRE, APECED
Tested Applications
WB, IF
Physical Properties
Liquid

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