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MAN2B1 Antibody

CAT: 0223-23-985Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-23-985Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E) . Next, the 70 kDa peptide is further processed into three peptides (A, B and C) . The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
4125
Swiss Prot
O00754
Host
Rabbit
Reactivity
Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 640-850 of human MAN2B1 (NP_000519.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse liver
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 170kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
MAN2B1
NCBI Official Name
Mannosidase alpha class 2B member 1
NCBI Organism
Homo sapiens
Other Product Names
LAMAN, MANB, lysosomal alpha-mannosidase, lysosomal acid alpha-mannosidase, mannosidase alpha-B, mannosidase, alpha B, lysosomal
Tested Applications
WB
Physical Properties
Liquid

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