CCNH Antibody

• Background:

  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK) . This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  902

• Swiss Prot:

  P51946

• Accession Number:

  P51946

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CCNH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-299 amino acids from the C-terminal region of human CCNH.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  38 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CCNH

• NCBI Official Name:

  Cyclin-H

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)

• Background Reference 02:

  Hosgood, H.D. III, et al. Respir Med 103 (12) :1866-1870 (2009)

• Background Reference 03:

  Young, R.P., et al. Postgrad Med85 (1008) :515-524 (2009)

• Background Reference 04:

  Kweekel, D.M., et al. Br. J. Cancer 101 (2) :357-362 (2009)

• Other Product Names:

  Cyclin-H, MO15-associated protein, p34, p37, CCNH

• Tested Applications:

  WB, Flow

• Protein ID:

  1706232

• Physical Properties:

  Liquid