SACA1 Antibody

• Background:

  The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively.

• NCBI Gene ID:

  81833

• Swiss Prot:

  Q9HBV2

• Accession Number:

  Q9HBV2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SACA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human SACA1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  32 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SPACA1

• NCBI Official Name:

  Sperm acrosome membrane-associated protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :

• Background Reference 02:

  Levy, D., et al. BMC Med. Genet.SUPPL 1, S3 (2007) :

• Background Reference 03:

  Vasan, R.S., et al. BMC Med. Genet.SUPPL 1, S2 (2007) :

• Background Reference 04:

  Mungall, A.J., et al. Nature 425 (6960) :805-811 (2003)

• Other Product Names:

  Sperm acrosome membrane-associated protein 1, Sperm acrosomal membrane-associated protein 32, SPACA1, SAMP32

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  74752784

• Physical Properties:

  Liquid