TMLHE Antibody

• Background:

  This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  55217

• Swiss Prot:

  Q9NVH6

• Accession Number:

  Q9NVH6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TMLHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the N-terminal region of human TMLHE.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  50 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TMLHE

• NCBI Official Name:

  Trimethyllysine dioxygenase, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Monfregola, J., et al. Gene 395 (1-2), 86-97 (2007) :

• Background Reference 02:

  Monfregola, J., et al. J. Cell. Physiol. 204 (3) :839-847 (2005)

• Background Reference 03:

  Vaz, F.M., et al. J. Biol. Chem. 276 (36) :33512-33517 (2001)

• Background Reference 04:

  Rogner, U.C., et al. Genome Res. 6 (10) :922-934 (1996)

• Other Product Names:

  Trimethyllysine dioxygenase, mitochondrial, Epsilon-trimethyllysine 2-oxoglutarate dioxygenase, Epsilon-trimethyllysine hydroxylase, TML hydroxylase, TML-alpha-ketoglutarate dioxygenase, TML dioxygenase, TMLD, TMLHE, TMLH

• Tested Applications:

  WB

• Protein ID:

  21542295

• Physical Properties:

  Liquid