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IBTK Antibody

CAT: 0223-55-375Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-375Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
NCBI Gene ID
25998
Swiss Prot
Q9P2D0
Accession Number
Q9P2D0
Host
Rabbit
Reactivity
Human
Immunogen
This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-613 amino acids from the Central region of human IBTK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
151 kDa
Fragment
Rabbit Ig
Symbol
IBTK
NCBI Official Name
Inhibitor of Bruton tyrosine kinase
NCBI Organism
Homo sapiens
Background Reference 01
Fiume, G., et al. Comput Biol Chem 33 (6) :434-439 (2009)
Background Reference 02
Spatuzza, C., et al. Nucleic Acids Res. 36 (13) :4402-4416 (2008)
Background Reference 03
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Background Reference 04
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Other Product Names
Inhibitor of Bruton tyrosine kinase, IBtk, IBTK, BTKI, KIAA1417
Tested Applications
WB, IHC-P, Flow
Protein ID
134034141
Physical Properties
Liquid

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