IBTK Antibody

• Background :

  The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.

• NCBI Gene ID :

  25998

• Swiss Prot :

  Q9P2D0

• Accession Number :

  Q9P2D0

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-613 amino acids from the Central region of human IBTK.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  151 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  IBTK

• NCBI Official Name :

  Inhibitor of Bruton tyrosine kinase

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Fiume, G., et al. Comput Biol Chem 33 (6) :434-439 (2009)

• Background Reference 02 :

  Spatuzza, C., et al. Nucleic Acids Res. 36 (13) :4402-4416 (2008)

• Background Reference 03 :

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Background Reference 04 :

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Other Product Names :

  Inhibitor of Bruton tyrosine kinase, IBtk, IBTK, BTKI, KIAA1417

• Tested Applications :

  WB, IHC-P, Flow

• Protein ID :

  134034141

• Physical Properties :

  Liquid