Products for Research Use Only
RegisterLogin

Grik4 Antibody

CAT: 0223-4393-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-4393-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Grik4 Antibody: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs) : GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder.
NCBI Gene ID
2900
Swiss Prot
Q16099
Accession Number
Q16099
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Grik4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
Grik4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Grik4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
GRIK4
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Glutamate receptor, ionotropic, kainate 4
NCBI Organism
Homo sapiens
Background Reference 01
Tanaka K. Functions of glutamate transporters in the brain. Neurosci. Res.2000; 37:15-9.
Background Reference 02
Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
Background Reference 03
Mayer ML. GRIK4 and the Kainate Receptor. Am. J. Psychiatry2007; 164:1148.
Background Reference 04
Pickard BS, Malloy MP, Christoforou A, et al. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol. Psychiatry2006; 11:847-57.
Other Product Names
Grik4 Antibody: KA1, EAA1, GRIK, GluK4, Glutamate receptor ionotropic, kainate 4, Excitatory amino acid receptor 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
209572625
Physical Properties
Liquid

Related Products

CatalogName
4393PGrik4 Peptide
4391PGrik4 Peptide
42-093GRIK5 Antibody
25-380GRIK5 Antibody
4383-01Grik1 Antibody
4381-01Grik1 Antibody
56-748GRIA4 Antibody
4383-002mgGrik1 Antibody
4397-01mgGrik5 Antibody
4383-01mgGrik1 Antibody

Alternative Products

CatalogName
20R-1334GRIK4 antibody

Popular Products