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COX10 Antibody

CAT: 0223-55-363Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-363Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
NCBI Gene ID
1352
Swiss Prot
Q12887
Accession Number
Q12887
Host
Rabbit
Reactivity
Human
Immunogen
This COX10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-410 amino acids from the C-terminal region of human COX10.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
49 kDa
Fragment
Rabbit Ig
Symbol
COX10
NCBI Official Name
Protoheme IX farnesyltransferase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Chen, Z., et al. Oncogene 29 (30) :4362-4368 (2010)
Background Reference 02
Vitali, M., et al.Neural Transm 116 (12) :1635-1641 (2009)
Background Reference 03
Dassa, E.P., et al. EMBO Mol Med 1 (1) :30-36 (2009)
Background Reference 04
Veluthakal, R., et al. Diabetes 56 (1) :204-210 (2007)
Other Product Names
Protoheme IX farnesyltransferase, mitochondrial, 251-, Heme O synthase, COX10
Tested Applications
WB, IHC-P, Flow
Protein ID
292495084
Physical Properties
Liquid

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