COX10 Antibody

• Background:

  Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.

• NCBI Gene ID:

  1352

• Swiss Prot:

  Q12887

• Accession Number:

  Q12887

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This COX10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-410 amino acids from the C-terminal region of human COX10.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  49 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  COX10

• NCBI Official Name:

  Protoheme IX farnesyltransferase, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen, Z., et al. Oncogene 29 (30) :4362-4368 (2010)

• Background Reference 02:

  Vitali, M., et al.Neural Transm 116 (12) :1635-1641 (2009)

• Background Reference 03:

  Dassa, E.P., et al. EMBO Mol Med 1 (1) :30-36 (2009)

• Background Reference 04:

  Veluthakal, R., et al. Diabetes 56 (1) :204-210 (2007)

• Other Product Names:

  Protoheme IX farnesyltransferase, mitochondrial, 251-, Heme O synthase, COX10

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  292495084

• Physical Properties:

  Liquid