UPF2 Antibody

• Background :

  UPF2 is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p.

• NCBI Gene ID :

  26019

• Swiss Prot :

  Q9HAU5

• Accession Number :

  Q9HAU5

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This UPF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 630-656 amino acids from the Central region of human UPF2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  148 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  UPF2

• NCBI Official Name :

  Regulator of nonsense transcripts 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Clerici, M., et al. EMBO J. 28 (15) :2293-2306 (2009)

• Background Reference 02 :

  Cronin, S., et al. Eur. J. Hum. Genet. 17 (2) :213-218 (2009)

• Background Reference 03 :

  Woeller, C.F., et al. EMBO Rep. 9 (5) :446-451 (2008)

• Background Reference 04 :

  Chamieh, H., et al. Nat. Struct. Mol. Biol. 15 (1) :85-93 (2008)

• Other Product Names :

  Regulator of nonsense transcripts 2, Nonsense mRNA reducing factor 2, Up-frameshift suppressor 2 homolog, hUpf2, UPF2, KIAA1408, RENT2

• Tested Applications :

  WB, Flow

• Protein ID :

  60390647

• Physical Properties :

  Liquid