APCS Antibody

• Background:

  The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

• NCBI Gene ID:

  325

• Swiss Prot:

  P02743

• Accession Number:

  P02743

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This APCS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-178 amino acids from the C-terminal region of human APCS.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  APCS

• NCBI Official Name:

  Serum amyloid P-component

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Song, Z., et al. Atherosclerosis 211 (1) :90-95 (2010)

• Background Reference 02:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Background Reference 03:

  McGeachie, M., et al. Circulation 120 (24) :2448-2454 (2009)

• Background Reference 04:

  Lu, J., et al. Nature 456 (7224) :989-992 (2008)

• Other Product Names:

  Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component (1-203), APCS, PTX2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  730704

• Physical Properties:

  Liquid