BARD1 Antibody

CAT: 0223-55-322Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-322Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BARD1 is a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
NCBI Gene ID
580
Swiss Prot
Q99728
Accession Number
Q99728
Host
Rabbit
Reactivity
Human
Immunogen
This BARD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human BARD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
87 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
BARD1
NCBI Official Name
BRCA1-associated RING domain protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Dizin, E., et al. Int. J. Biochem. Cell Biol. 42 (5) :693-700 (2010)
Background Reference 04
Irminger-Finger, I. Gynecol. Oncol. 117 (2) :211-215 (2010)
Other Product Names
BRCA1-associated RING domain protein 1, BARD-1, 632-, BARD1
Tested Applications
WB
Protein ID
116241265
Physical Properties
Liquid

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