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NCALD Antibody

CAT: 0223-55-219Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-219Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NCALD encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined.
NCBI Gene ID
83988
Swiss Prot
P61601
Accession Number
P61601
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This NCALD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-174 amino acids from the C-terminal region of human NCALD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Pig, Rat, Chicken, Monkey, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NCALD
NCBI Official Name
Neurocalcin-delta
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18 (7) :815-820 (2010)
Background Reference 03
Gill, M.B., et al. J. Biol. Chem. 284 (21) :14503-14512 (2009)
Background Reference 04
Venkataraman, V., et al. Biochemistry 47 (25) :6590-6601 (2008)
Other Product Names
Neurocalcin-delta, NCALD
Tested Applications
WB
Protein ID
47606440
Physical Properties
Liquid

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MBS8504311-01NCALD Antibody

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