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ENSA Antibody

CAT: 0223-55-188Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-188Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ENSA belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes.
NCBI Gene ID
2029
Swiss Prot
O43768
Accession Number
O43768
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ENSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human ENSA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Pig, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
13 kDa
Fragment
Rabbit Ig
Symbol
ENSA
NCBI Official Name
Alpha-endosulfine
NCBI Organism
Homo sapiens
Background Reference 01
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Background Reference 02
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 03
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 04
Gabrielsson, B.G., et al. Mol. Cell. Biochem. 258 (1-2), 65-71 (2004) :
Other Product Names
Alpha-endosulfine, ARPP-19e, ENSA
Tested Applications
WB, Flow
Physical Properties
Liquid

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