ENSA Antibody

• Background:

  ENSA belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes.

• NCBI Gene ID:

  2029

• Swiss Prot:

  O43768

• Accession Number:

  O43768

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This ENSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human ENSA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Pig, Rat, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  13 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ENSA

• NCBI Official Name:

  Alpha-endosulfine

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Background Reference 02:

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Background Reference 03:

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Background Reference 04:

  Gabrielsson, B.G., et al. Mol. Cell. Biochem. 258 (1-2), 65-71 (2004) :

• Other Product Names:

  Alpha-endosulfine, ARPP-19e, ENSA

• Tested Applications:

  WB, Flow

• Physical Properties:

  Liquid