CD86 Antibody [CDLA86]

• Background :

  CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is a receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. [UniProt]

• NCBI Gene ID :

  942

• Swiss Prot :

  P42081

• Host :

  Mouse

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant human full-length protein was used as the immunogen for the CD86 antibody.

• Clonality :

  Monoclonal

• Clone :

  CDLA86

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology, Signal Transduction

• Purification :

  Protein G affinity chromatography

• Concentration :

  0.2 mg/mL

• Buffer :

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment :

  IgG1, kappa

• Applications Notes :

  1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.

• Symbol :

  CD86

• NCBI Official Name :

  CD86 molecule

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B72, FUN-1, CD86, CD86, CD28LG2

• Tested Applications :

  Flow, IF, WB, IHC-P

• Physical Properties :

  Liquid