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CD86 Antibody [GL1]

CAT: 223-98-852Size: 0.5 mgDry Ice: NoHazardous: No
0.5 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD86, also known as B7-2, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B-cell specific stimuli with peak expression at 18-42 hours after stimulation. CD86, along with CD80 (B7-1), is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152 (CTLA-4) . Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. The monoclonal antibody GL1 blocks mixed lymphocyte reactions and stimulation of T cells by antigen-presenting cells.
NCBI Gene ID
12524
Swiss Prot
P42082
Accession Number
P42082
Host
Rat
Reactivity
Mouse
Immunogen
LPS-activated CBA/Ca mouse spleen B cells
Clonality
Monoclonal
Clone
[GL1]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG2a
Specificity
CD86
Applications Notes
CD86 Antibody [GL1] for use in flow cytometry, immunohistochemistry, immunoprecipitation, and blocking assays.
Symbol
Cd86
NCBI Official Name
CD86 antigen
NCBI Organism
Mus musculus
Other Product Names
B7-2, B70, Ly-58
Tested Applications
Flow
Physical Properties
Liquid

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