CD86 Antibody [GL1]

• Background:

  CD86, also known as B7-2, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B-cell specific stimuli with peak expression at 18-42 hours after stimulation. CD86, along with CD80 (B7-1), is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152 (CTLA-4) . Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. The monoclonal antibody GL1 blocks mixed lymphocyte reactions and stimulation of T cells by antigen-presenting cells.

• NCBI Gene ID:

  12524

• Swiss Prot:

  P42082

• Accession Number:

  P42082

• Host:

  Rat

• Reactivity:

  Mouse

• Immunogen:

  LPS-activated CBA/Ca mouse spleen B cells

• Clonality:

  Monoclonal

• Clone:

  [GL1]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Concentration:

  0.5 mg/mL

• Buffer:

  Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG2a

• Specificity:

  CD86

• Applications Notes:

  CD86 Antibody [GL1] for use in flow cytometry, immunohistochemistry, immunoprecipitation, and blocking assays.

• Symbol:

  Cd86

• NCBI Official Name:

  CD86 antigen

• NCBI Organism:

  Mus musculus

• Other Product Names:

  B7-2, B70, Ly-58

• Tested Applications:

  Flow

• Physical Properties:

  Liquid