CD8a Antibody [CLDA8a-1]

CAT: 0223-33-889Size: 100 µgDry Ice: NoHazardous: No
CAT#:0223-33-889Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
CD8 is a cell surface receptor expressed either as a heterodimer with the beta chain or as a homodimer. A majority of thymocytes and a subpopulation of mature Tcells and NK cells express CD8a. It binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in Tcell development and activation of mature Tcells. For mature Tcells, CD8 and 4 are mutually exclusive, so antibody to CD8 is generally used in conjunction with antibody to CD4. CD8a antibody is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral Tcell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+/CD8-, and in T-lymphoblastic lymphoma/leukemia, they are often co-expressed. It is also found in littoral cell angioma of the spleen.
NCBI Gene ID
925
Swiss Prot
P01732
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant protein was used as the immunogen for this CD8a antibody.
Clonality
Monoclonal
Clone
CLDA8a-1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1
Applications Notes
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. 2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Symbol
CD8A
NCBI Official Name
CD8a molecule
NCBI Organism
Homo sapiens
Other Product Names
T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL
Tested Applications
Flow, IF, IHC
Physical Properties
Liquid

Related Products

CatalogName
57-511CD8A Antibody
14-172CD8A Antibody
57-512CD8A Antibody
76-637CD8a Antibody [Hit8a]
99-306CD8a Antibody [EP72]
33-280CD8a Antibody [RIV11]
33-281CD8a Antibody [SPM548]
76-642CD8a Antibody [Hit8a] (PE)
76-643CD8a Antibody [Hit8a] (PE)
76-673CD8a Antibody [OKT8] (APC)

Alternative Products

CatalogName
CL009FXCd8a Mouse Monoclonal Antibody [Clone ID: 49-31.1]
CL009Cd8a mouse monoclonal antibody, clone 49-31.1, Ascites
BM4102Cd8a Mouse Monoclonal Antibody [Clone ID: Rib 6/1]
V8216-100UGCD8a Antibody

Popular Products