CD8A Antibody

• Background:

  The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.

• NCBI Gene ID:

  925

• Swiss Prot:

  P01732

• Accession Number:

  P01732

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-88 amino acids from the N-terminal region of human CD8A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  26 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CD8A

• NCBI Official Name:

  T-cell surface glycoprotein CD8 alpha chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mancebo, E., Mol. Immunol. 45 (2), 479-484 (2008)

• Background Reference 02:

  Zhou, H., Transplant. Proc. 39 (10), 3065-3067 (2007)

• Background Reference 03:

  Borchers, M.T., Exp. Mol. Pathol. 83 (3), 301-310 (2007)

• Other Product Names:

  T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL

• Tested Applications:

  WB, IHC-P

• Protein ID:

  116035

• Physical Properties:

  Liquid