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CD8A Antibody

CAT: 0223-57-511Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-511Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
NCBI Gene ID
925
Swiss Prot
P01732
Accession Number
P01732
Host
Rabbit
Reactivity
Human
Immunogen
This CD8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-88 amino acids from the N-terminal region of human CD8A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Symbol
CD8A
NCBI Official Name
T-cell surface glycoprotein CD8 alpha chain
NCBI Organism
Homo sapiens
Background Reference 01
Mancebo, E., Mol. Immunol. 45 (2), 479-484 (2008)
Background Reference 02
Zhou, H., Transplant. Proc. 39 (10), 3065-3067 (2007)
Background Reference 03
Borchers, M.T., Exp. Mol. Pathol. 83 (3), 301-310 (2007)
Other Product Names
T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL
Tested Applications
WB, IHC-P
Protein ID
116035
Physical Properties
Liquid

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