Prostate Specific Antibody [PSAK3-1]

• Background:

  Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. Prostate specific antigen/KLK3 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. [RefSeq]

• NCBI Gene ID:

  354

• Swiss Prot:

  P07288

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant full-length human PSA protein was used as the immunogen for the Prostate Specific antibody.

• Clonality:

  Monoclonal

• Clone:

  PSAK3-1

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Applications Notes:

  1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes 2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

• Symbol:

  KLK3

• NCBI Official Name:

  Kallikrein-related peptidase 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Prostate-specific antigen, PSA, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS

• Tested Applications:

  IF, IHC-P

• Physical Properties:

  Liquid