HLA-DR Antibody [169-1B5.2]

• Background:

  This antibody detects a monomorphic general framework determinant of HLA-DR Class II antigen. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.

• NCBI Gene ID:

  3122

• Swiss Prot:

  P01903

• Host:

  Mouse

• Reactivity:

  Human, Bovine, Cat

• Immunogen:

  Human peripheral blood leukocytes were used as the immunogen for the HLA-DR antibody.

• Clonality:

  Monoclonal

• Clone:

  169-1B5.2

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG2b, kappa

• Symbol:

  HLA-DRA

• NCBI Official Name:

  Major histocompatibility complex, class II, DR alpha

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen DRA, HLA-DRA, HLA-DRA1

• Tested Applications:

  WB, Flow, IF

• Physical Properties:

  Liquid