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CD80 Antibody [C80/1608]

CAT: 0223-33-664Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-33-664Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.
NCBI Gene ID
941
Swiss Prot
P33681
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein used as the immunogen for the CD80 antibody.
Clonality
Monoclonal
Clone
C80/1608
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
CD80
NCBI Official Name
CD80 molecule
NCBI Organism
Homo sapiens
Other Product Names
T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B71, B7, CD80, CD80, CD28LG, CD28LG1, LAB7
Tested Applications
Flow, IF, ELISA
Physical Properties
Liquid

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