UACA Antibody [UACA/1222]

• Background :

  UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

• NCBI Gene ID :

  55075

• Swiss Prot :

  Q9BZF9

• Host :

  Mouse

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant human protein was used as the immunogen for the UACA antibody.

• Clonality :

  Monoclonal

• Clone :

  UACA/1222

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  Protein G affinity chromatography

• Concentration :

  0.2 mg/mL

• Buffer :

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment :

  IgG1, kappa

• Symbol :

  UACA

• NCBI Official Name :

  Uveal autoantigen with coiled-coil domains and ankyrin repeats

• NCBI Organism :

  Homo sapiens

• Tested Applications :

  Flow, IF, WB

• Physical Properties :

  Liquid