Lambda Light Chain Antibody [ICO-106]

• Background:

  This antibody is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. In general the ratio of Kappa to Lambda is 3:1. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

• NCBI Gene ID:

  3535

• Swiss Prot:

  P01701; P01842

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Purified human Ig was used as the immunogen for this Lambda light chain antibody.

• Clonality:

  Monoclonal

• Clone:

  ICO-106

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Applications Notes:

  1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

• Symbol:

  IGL

• NCBI Official Name:

  Immunoglobulin lambda locus

• NCBI Organism:

  Homo sapiens

• Tested Applications:

  WB, Flow, IHC

• Physical Properties:

  Liquid