Human Lambda Light Chain (ICO-106), 0.2mg/mL

CAT: 0037-BNUB0019-500Size: 1x 500 µLDry Ice: NoHazardous: No
CAT#:0037-BNUB0019-500Size:1x 500 µL
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Description
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
Bence Jones Protein; BJP; IGLC 1/2/3; Mcg Marker; Paraprotein
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
IGL
Gene ID
3535 & 3546
NCBI Gene ID
449585
UniProt
P01701; P01842
Swiss Prot
P01701 & P01842
Host
Mouse
Species Reactivity
Human
Reactivity
Human Lambda Light Chain
Immunogen
Purified human IgG
Target Antigen
Human Lambda Light Chain
Clonality
Monoclonal
Clone
ICO-106
Type
Anti-Human Immunoglobulin|Primary
Source
Animal
Origin
Animal
Field of Research
Cancer, Immunology, Inflammation
Positive Control
293T, Raji or hPBL cells. Tonsil or Spleen
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
~22.5 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate
Purified, with BSA
Product Datasheet
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