Lambda Light Chain Antibody [N10/2]

CAT: 0223-33-632Size: 100 µgDry Ice: NoHazardous: No
CAT#:0223-33-632Size:100 µg
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Background
Individual B-cells in lymphoid tissue possess either kappa or lambda light chains, but never both together. Specific rearrangement of lambda light chain of immunoglobulins can lead to loss of some protein coding genes, which does not seem to be functionally relevant (while functionally relevant miR-650 can be overexpressed) . Using immunohistochemistry, it is possible to determine the relative abundance of B-cells expressing kappa and lambda light chains. If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell lymphoma. [Wiki]
NCBI Gene ID
28820
Swiss Prot
P01701, P01842
Host
Mouse
Reactivity
Human
Immunogen
IgG purified from human serum was used as the immunogen for this Lambda Light Chain antibody.
Clonality
Monoclonal
Clone
N10/2
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
IGLV1-51, cycH
NCBI Official Name
Immunoglobulin lambda variable 1-51
NCBI Organism
Homo sapiens, Pseudomonas syringae
Tested Applications
Flow, IF, WB, IHC
Physical Properties
Liquid

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