Fibronectin Antibody [TV-1]

• Background:

  This antibody reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this antibody localizes to tumor vessels where it binds to the underlying basement. The Fibronectin epitope recognized by this antibody is not accessible in normal tissues to the circulating antibody indicating that it can be used to specifically target tumor vessels in vivo. Clone TV-1 fibronectin antibody is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or antibodies.

• NCBI Gene ID:

  2335

• Swiss Prot:

  P02751

• Host:

  Mouse

• Reactivity:

  Human, Pig, Mouse, Rat

• Immunogen:

  A T-cell lymphoma biopsy was used as the immunogen for this fibronectin antibody.

• Clonality:

  Monoclonal

• Clone:

  TV-1

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Applications Notes:

  1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

• Symbol:

  FN1

• NCBI Official Name:

  Fibronectin 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  FN1, CIG, DKFZp686F10164, DKFZp686H0342, DKFZp686I1370, DKFZp686O13149, FINC, FN, LETS, MSF, FNZ, ED-B, GFND, GFND2

• Tested Applications:

  Flow, IHC, IF

• Physical Properties:

  Liquid