CYLD Antibody

• Background :

  CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.

• NCBI Gene ID :

  1540

• Swiss Prot :

  Q9NQC7

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  Protein A affinity chromatography

• Concentration :

  0.5 mg/mL

• Buffer :

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.

• Fragment :

  IgG

• Symbol :

  CYLD

• NCBI Official Name :

  CYLD lysine 63 deubiquitinase

• NCBI Organism :

  Homo sapiens

• Tested Applications :

  WB

• Physical Properties :

  Liquid