CYLD Antibody

• Background:

  CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.

• NCBI Gene ID:

  1540

• Swiss Prot:

  Q9NQC7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  Protein A affinity chromatography

• Concentration:

  0.5 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG

• Symbol:

  CYLD

• NCBI Official Name:

  CYLD lysine 63 deubiquitinase

• NCBI Organism:

  Homo sapiens

• Tested Applications:

  WB

• Physical Properties:

  Liquid