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GABBR2 Antibody

CAT: 0223-55-090Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-090Size:400 µL
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Background
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
NCBI Gene ID
9568
Swiss Prot
O75899
Accession Number
O75899
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-890 amino acids from the C-terminal region of human GABBR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
106 kDa
Fragment
Rabbit Ig
Symbol
GABBR2
NCBI Official Name
Gamma-aminobutyric acid type B receptor subunit 2
NCBI Organism
Homo sapiens
Background Reference 01
Oblak, A.L., et al. J. Neurochem. 114 (5) :1414-1423 (2010)
Background Reference 02
Letra, A., et al. Am. J. Med. Genet.152A (7), 1701-1710 (2010) :
Background Reference 03
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 04
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Other Product Names
Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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