GABBR2 Antibody

• Background:

  The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

• NCBI Gene ID:

  9568

• Swiss Prot:

  O75899

• Accession Number:

  O75899

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-890 amino acids from the C-terminal region of human GABBR2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  106 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GABBR2

• NCBI Official Name:

  Gamma-aminobutyric acid type B receptor subunit 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Oblak, A.L., et al. J. Neurochem. 114 (5) :1414-1423 (2010)

• Background Reference 02:

  Letra, A., et al. Am. J. Med. Genet.152A (7), 1701-1710 (2010) :

• Background Reference 03:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04:

  Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

• Other Product Names:

  Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid