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FUS Antibody

CAT: 0223-55-074Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-074Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
NCBI Gene ID
2521
Swiss Prot
P35637
Accession Number
P35637
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This FUS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-526 amino acids from the C-terminal region of human FUS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Symbol
FUS
NCBI Official Name
RNA-binding protein FUS
NCBI Organism
Homo sapiens
Background Reference 01
Kim, S.H., et al. J. Biol. Chem. 285 (44) :34097-34105 (2010)
Background Reference 02
Mackenzie, I.R., et al. Lancet Neurol 9 (10) :995-1007 (2010)
Background Reference 03
Yan, J., et al. Neurology 75 (9) :807-814 (2010)
Background Reference 04
Waibel, S., et al. Neurology 75 (9) :815-817 (2010)
Other Product Names
RNA-binding protein FUS, 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS, POMp75, Translocated in liposarcoma protein, FUS, TLS
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
544357
Physical Properties
Liquid

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