ABCC3 Antibody

• Background:

  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

• NCBI Gene ID:

  8714

• Swiss Prot:

  O15438

• Accession Number:

  O15438

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ABCC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 899-925 amino acids from the Central region of human ABCC3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  169 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ABCC3

• NCBI Official Name:

  Canalicular multispecific organic anion transporter 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Hoffman, A.D., et al. Protein J. 29 (5) :373-379 (2010)

• Background Reference 03:

  Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

• Background Reference 04:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Other Product Names:

  Canalicular multispecific organic anion transporter 2, ATP-binding cassette sub-family C member 3, Multi-specific organic anion transporter D, MOAT-D, Multidrug resistance-associated protein 3, ABCC3, CMOAT2, MLP2, MRP3

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid