ABCC3 Antibody

CAT: 0223-55-057Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-057Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
NCBI Gene ID
8714
Swiss Prot
O15438
Accession Number
O15438
Host
Rabbit
Reactivity
Human
Immunogen
This ABCC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 899-925 amino acids from the Central region of human ABCC3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
169 kDa
Fragment
Rabbit Ig
Symbol
ABCC3
NCBI Official Name
Canalicular multispecific organic anion transporter 2
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Hoffman, A.D., et al. Protein J. 29 (5) :373-379 (2010)
Background Reference 03
Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)
Background Reference 04
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Other Product Names
Canalicular multispecific organic anion transporter 2, ATP-binding cassette sub-family C member 3, Multi-specific organic anion transporter D, MOAT-D, Multidrug resistance-associated protein 3, ABCC3, CMOAT2, MLP2, MRP3
Tested Applications
WB, IHC-P, Flow
Physical Properties
Liquid

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