PARL Antibody

CAT: 0223-31-364Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-31-364Size:100 µL
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Background
PARL is a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. PARL may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in its gene has been associated with increased risk for type 2 diabetes.This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI Gene ID
55486
Swiss Prot
Q9H300-2
Accession Number
NP_001032728
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PARL.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PARL antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
36 kDa, 42 kDa
Applications Notes
PARL antibody can be used for detection of PARL by ELISA at 1:312500. PARL antibody can be used for detection of PARL by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PARL
NCBI Official Name
Presenilin associated, rhomboid-like
NCBI Organism
Homo sapiens
Background Reference 01
Walder, K., (2005) Diabetologia 48 (3), 459-468.
Other Product Names
PARL, PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Tested Applications
ELISA, WB, IHC
Protein ID
83641878
Physical Properties
Liquid

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