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TGFBR2 Antibody

CAT: 0223-31-354Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-31-354Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NCBI Gene ID
7048
Swiss Prot
P37173
Accession Number
NP_003233
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TGFBR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TGFBR2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
62 kDa, 67 kDa
Applications Notes
TGFBR2 antibody can be used for detection of TGFBR2 by ELISA at 1:312500. TGFBR2 antibody can be used for detection of TGFBR2 by western blot at 5.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
TGFBR2
NCBI Official Name
Transforming growth factor, beta receptor II (70/80kDa)
NCBI Organism
Homo sapiens
Background Reference 01
Song, K., (2006) J. Biol. Chem. 281 (12), 7765-7774.
Other Product Names
TGFBR2, HNPCC6, MFS2, RIIC, Tbeta, AAT3, FAA3, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII
Tested Applications
ELISA, WB
Protein ID
67782324
Physical Properties
Liquid

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