AGPAT2 Antibody

• Background:

  AGPAT2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in its gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance.This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

• NCBI Gene ID:

  10555

• Swiss Prot:

  Q5VUD3

• Accession Number:

  NP_001012745

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human AGPAT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Membrane, Cancer

• Purification:

  Antibody is purified by protein A chromatography method.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store AGPAT2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  27 kDa, 31 kDa

• Applications Notes:

  AGPAT2 antibody can be used for detection of AGPAT2 by ELISA at 1:312500. AGPAT2 antibody can be used for detection of AGPAT2 by western blot at 5.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  AGPAT2

• NCBI Official Name:

  1-acylglycerol-3-phosphate O-acyltransferase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Niesporek, S., (2005) Br. J. Cancer 92 (9), 1729-1736.

• Other Product Names:

  AGPAT2, 1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta

• Tested Applications:

  ELISA, WB

• Protein ID:

  69122971

• Physical Properties:

  Liquid