GTF2H2 Antibody

CAT: 0223-31-217Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-31-217Size:100 µL
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Background
GTF2 is encoded by a gene that is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.
NCBI Gene ID
2966
Swiss Prot
Q13888
Accession Number
NP_001506
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GTF2H2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store GTF2H2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
44 kDa
Applications Notes
GTF2H2 antibody can be used for detection of GTF2H2 by ELISA at 1:1562500. GTF2H2 antibody can be used for detection of GTF2H2 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
GTF2H2
NCBI Official Name
General transcription factor IIH, polypeptide 2, 44kDa
NCBI Organism
Homo sapiens
Background Reference 01
Le May, N., et al., (2004) Cell 116 (4), 541-550.
Other Product Names
GTF2H2, p44, BTF2, TFIIH, BTF2P44, T-BTF2P44
Tested Applications
ELISA, WB, IHC
Protein ID
6681762
Physical Properties
Liquid

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