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CAV1 Antibody

CAT: 0223-31-073Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-31-073Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The scaffolding protein is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression.The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
NCBI Gene ID
857
Swiss Prot
Q03135
Accession Number
NP_001744
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CAV1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CAV1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
20 kDa
Applications Notes
CAV1 antibody can be used for detection of CAV1 by ELISA at 1:312500. CAV1 antibody can be used for detection of CAV1 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
CAV1
NCBI Official Name
Caveolin 1, caveolae protein, 22kDa
NCBI Organism
Homo sapiens
Background Reference 01
Wehner, K.A. Am. J. Physiol., Cell Physiol. 290 (5), C1273-C1274 (2006) .
Other Product Names
CAV1, CAV, MSTP085, VIP21, CGL3, PPH3, BSCL3
Tested Applications
ELISA, WB, IHC
Protein ID
15451856
Physical Properties
Liquid

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