CBX2 Antibody

• Background:

  CBX2 Contains 1 A.T hook DNA-binding domain and 1 chromo domain. CBX2 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

• NCBI Gene ID:

  84733

• Swiss Prot:

  Q14781

• Accession Number:

  NP_005180

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CBX2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1301 - Human Heart Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CBX2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  56 kDa

• Applications Notes:

  CBX2 antibody can be used for detection of CBX2 by ELISA at 1:1562500. CBX2 antibody can be used for detection of CBX2 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  CBX2

• NCBI Official Name:

  Chromobox homolog 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Garcia, E., (1999) EMBO J. 18 (12), 3404-3418.

• Other Product Names:

  CBX2, CDCA6, M33, MGC10561, SRXY5

• Tested Applications:

  ELISA, WB

• Protein ID:

  61743963

• Physical Properties:

  Liquid